英国邓迪大学招聘帕金森病研究博士后

Grade 7 (£29,837 – £36,661)

Postdoctoral positions in the laboratory of Dr Miratul Muqit in collaboration with Professor Dario Alessi FRS to unravel the regulation and downstream function of signalling pathways disrupted in Parkinson’s disease.

Applications are invited for two Postdoctoral Researchers to work in the laboratory of Miratul Muqit to elucidate the role of the PINK1 kinase and/or the Parkin E3 ligase that are linked to the development of Parkinson’s disease. The research is funded by the Wellcome Trust as part of a Senior Fellowship award to Dr Muqit and will be undertaken in collaboration with Dario Alessi’s lab in the MRC unit. Dr Muqit’s lab recently identified Parkin as a physiological substrate for PINK1 and elaborated the first signaling pathway whose disruption leads to Parkinson’s. This discovery has led to new exciting questions relating to the regulation and downstream functions of PINK1 and Parkin.

The successful applicant will have access to state-of-the-art technologies in biochemistry, genome editing, cell biology, proteomics, and transgenic mouse models to uncover new fundamental knowledge on these key enzymes. The MRC unit also collaborates with six major pharmaceutical companies that support the Division of Signal Transduction Therapy that provides opportunities to exploit the therapeutic potential of new discoveries made in the lab.

Candidate requirements:

- PhD with an outstanding track record and at least one first authored publication in an internationally recognised peer-reviewed journal.
- Strong background in Biochemistry, Molecular Biology, Signal Transduction and or Pharmacology would be preferable.
- Experience and strong interest in Protein Phosphorylation or Ubiquitylation research would be preferable.
- Capable of working in a team, but able to plan and work independently.
- Excellent communication skills and proficiency in English.

The positions are for 3 years. 



For informal enquiries please contact Miratul Muqit m.muqit@dundee.ac.uk. For details on the Muqit lab please visit our website: http://www.ppu.mrc.ac.uk/research/?pid=11 .

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):

The Muqit lab is based in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the College of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk ). Many world leading researchers in the field of signal transduction have trained within the MRC-PPU. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the College of Life Sciences at the University of Dundee which is one of the premier Life Sciences research Centres in the world