英国癌症研究院分子病理学博士后职位

Job Title: Post-doctoral Training Fellow – Molecular Pathology

Closing Date of vacancy: 26 March 2014

Division: Molecular Pathology

Team: Molecular Pathways & Target Discovery

Type of Contract: Fixed Term

Length of Contract: 24 months in the first instance

Salary Range: £28,425 – £40,628 p.a. inclusive (full scale)

Work Location: Sutton (Surrey)

Hours per week: 35

The Institute of Cancer Research (ICR) is one of the world’s most influential cancer research institutes. Our mission is to make the discoveries that defeat cancer. We have a long and distinguished history of research with a major impact on the outcome for cancer patients. Our unique partnership with The Royal Marsden NHS Foundation Trust (RMH) makes us the largest comprehensive cancer centre in Europe, performing high quality original basic research and translational studies. Under the leadership of Chief Executive Professor Alan Ashworth FRS, we are committed to attracting, developing and retaining the best minds in the world. The ICR was ranked as the UK’s top academic research centre in the 2008 Higher Education Funding Council Research Assessment Exercise. Based on our publication record, citations and impact we rank among the world’s leading cancer research centres.

Aposition for a Postdoctoral Training Fellow is available from April 2014 in the Division of Molecular Pathology, led by Professor Markus Müschen, at The Institute of Cancer Research based in Sutton. The project will be to employ phospho-proteomics and mass spectrometry to study the biology of tyrosine kinase and RAS-MAPK signalling in B cell malignancies. The aim of the project is to build a fundamental understanding of (1) why tyrosine-kinase-driven B cell leukaemias are uniquely sensitive to loss of negative feedback; (2) why tyrosine-kinase-driven B cell leukaemias can only thrive within the limits of a ‘comfort zone’ of oncogene signalling, with either attenuation (TKI) or hyperactivation (blockade of feedback) leading to cell death; and (3) how ablation of negative feedback can be leveraged towards a novel approach in cancer medicine. For more information see http://www.wellcome.ac.uk/Funding/Biomedical-science/Funded-projects/Awards-made/wtvm054834.htm.

This is an ideal opportunity for a committed and enthusiastic scientist to apply network biology in the mechanistic understanding of oncogene-feedback interactions. The successful candidate will work as part of a multi-disciplinary team in a well-equipped laboratory.

Applicants will hold a PhD in Biochemistry, Molecular Biology, Cancer Biology or a similar discipline, and have good laboratory and analytical skills with experience in working in a collaborative environment. We are interested in candidates with previous experience in Cancer Biology or Oncogene Signalling. Experience in working with xenograft models would be an advantage for this position. A demonstrable knowledge in protein mass spectrometry would also be desirable. Candidates are expected to have at least one first author peer reviewed publication.

Starting salary will be in the range £28,425 – £34,944 p.a. inclusive based on postdoctoral experience and relevance of skills. The appointment offered on a fixed term contract of 24 months in the first instance. The full scale for the post is £28,425 p.a. – £40,628 p.a. inclusive.