美国NIH癌症基因组学和精密的免疫疗法方向博士后

Cancer Genomics and Precision Immunotherapy

Posted by: Postdoc positions by NIH

Location: USA

Position Description:
At Memorial Sloan Kettering (MSK), we're not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we're driving excellence and improving outcomes. For the 26th year, MSK has been named a top hospital for cancer by U.S. News & World Report. We're treating cancer, one patient at a time. Join us and make a difference every day.

The Immunogenomics and Precision Oncology Platform (IPOP) is a newly established research program at MSK. IPOP is dedicated to developing precision immunotherapy at MSK. The program's goal is to unravel the molecular determinants of response to immunotherapy and to optimize immunotherapeutics such as immune checkpoint inhibitors and neoantigen-based vaccines using large-scale analyses.

We are seeking a highly motivated candidate with a background in molecular/cellular biology to work at the interface of cancer genetics, genomic analysis, and tumor immunology.

The successful candidate will work on the analysis of genomic datasets, perform experiments functionally characterizing tumor suppressor genes and oncogenes in vitro and in vivo, and carry out analyses linking findings in the tumor genome to the tumor immune microenvironment. 

Potential projects include but are not limited to multi-omic datasets of head and neck and other cancer types treated with immunotherapy, investigating tumor suppressor genes relevant to head and neck carcinogenesis, developing new immunocompetent mouse models of head and neck tumors, and immunologic interrogations of checkpoint blockade, combination therapies, and neoantigen screens in patient tumors and model systems.

The IPOP group and Chan Laboratory together comprise a dynamic group of over 20 scientists working collaboratively across spectrum of cancer research, from basic molecular genetics, tumor immunology, mouse modeling, to computational biology and bioinformatics.

Approaches utilized include sequencing of exomes, transcriptomes, and T cell repertoires, as well as neoantigen immunogenicity screens, molecular cloning, biochemistry, and mouse models.

Qualifications:
Applicants should hold a top-tier PhD and/or MD degree and have strong laboratory and analytical skills. Significant experience in molecular biology, immunology and cancer biology is required. Good communication and organizational skills are a must. Bioinformatics knowledge is preferred. This position requires cross-disciplinary and strong analytical skills as well as broad experience in immunology and molecular biology.

To Apply:
Full applications including curriculum vitae, a summary of current and future research interests and expected availability date, a description of past research experience and accomplishments, selected reprints of publications and three references.