美国哥伦比亚大学2019年博士后招聘（干细胞生物学/神经生物学方向）

招聘简介：

纽约市哥伦比亚大学欧文医学中心分子遗传学部的Doege和Thaker实验室正在寻找一位具有干细胞生物学和/或神经生物学专业知识的博士后研究科学家，以研究新型肥胖变体的分子遗传学。我们的工作重点是利用下一代测序技术在患有严重肥胖的儿童和成人中识别罕见的基因变异，并在患者特异性多能干细胞衍生神经元模型中进行验证。Doege博士是一名干细胞生物学家，Thaker博士是一名具有计算生物学专业知识的儿科内分泌学家。我们可以一起解决从床边到长椅的问题，把治疗方法带回床边。合格的髁突动物将接触到包括干细胞生物学、单细胞和大块RNA测序以及人类临床研究在内的尖端技术。

英文原文：

The Doege and Thaker labs in the Division of Molecular Genetics at Columbia University Irving Medical Center in New York City are seeking a highly motivated Postdoctoral Research Scientist with expertise in stem cell biology and/or neurobiology to study the molecular genetics of novel obesity variants. Our work focuses on identifying rare genetic variants in children and adults with severe obesity using next generation sequencing, and its validation in patient-specific pluripotent stem cell derived neuronal models. Dr. Doege is a stem-cell biologist and Dr. Thaker is a pediatric endocrinologist with expertise in computational biology. Together, we are able to take problems from the bedside to bench and bring the therapies back to the bedside. The eligible condidate will have exposure to cutting edge technologies including stem cell biology, single cell and bulk RNAsequencing as well as clinical research in humans.

The eligible candidate will join a highly interactive and collaborative research team that works on creation and molecular characterization of mutation-specific human stem cell-derived hypothalamic neurons. The project will focus on identifying RNAexpression profile of patient specific hypothalamic neurons intersecting with whole genome sequencing data to identify functional changes giving rise to extreme human phenotype. The postdoctoral candidate should have a strong interest in human stem cell biology and/or neurobiology. Previous expertise and/or interest in stem cell biology, next-gen sequencing technologies, and genomics is preferred, but not necessary. Motivation, strong interpersonal and communication skills including fluency in spoken and written English and excellence in scientific rigor is valued more than previous field of study. Advanced degree in Biological Sciences such as PhD or MD/PhD is required. The candidate will benefit from an interdisciplinary and collegial environment at Columbia and the vibrant and supportive atmosphere of a junior lab. Salary is competitive based on qualifications.

Applicants should send curriculum vitae, statement of interest, and contact information for three references to:

Claudia Doege

cad2114@cumc.columbia.edu

and

Vidhu Thaker

vvt2114@cumc.columbia.edu