美国爱因斯坦医学院发育和分子生物学招聘博士后

A postdoctoral position for an outstanding and highly motivated candidate with experience in Drosophila genetics and microscopic methods is available in the Department of Developmental and Molecular Biology at the Albert Einstein College of Medicine. More information can be found at http://jennylab.aecom.yu.edu/.

Our laboratory focuses on molecular aspects of canonical and non-canonical Wnt signaling. We are particularly interested how cells polarize with respect to the epithelial plane. Planar cell polarity (PCP) is a feature of a wide variety of epithelia, including the arrangement of feathers on birds, hair on mammalian skin or such elaborate structures as the cilia on inner ear sensory cells essential for hearing. Aberrant PCP signaling can lead to left/right asymmetry inversions, heart and neural tube defects and cystic kidneys. PCP signaling is highly conserved from Drosophila to ascidians and humans. Using the genetic and biochemical tools available with Drosophila as a model system, we study how a directional signal is transmitted and interpreted by individual or groups of cells.
Rho kinase integrates PCP signaling input with the regulation of the actin cytoskeleton and its function impacts cell migration during many processes. Furthermore, Rho kinase is required for cell migration of metastasizing cells across epithelial cell layers. We recently performed a systematic in vitro screen for novel Rho kinase substrates. The postdoc will address the role of these substrates in vivo and in vitro using genetic and biochemical methods.
The candidate’s research will benefit from a lively and friendly atmosphere and a strong tradition of collaboration within the College. Albert Einstein College of Medicine is situated in the Bronx, one of the five boroughs of New York City and offers ready access to the cultural and recreational opportunities in Manhattan and the greater New York area.