英国邓迪大学生命科学院招聘博士后

Grade 7 (£29,541 – £36,298)

Postdoctoral positions in the Laboratory of Professor Dario Alessi FRS-to unravel the role of signalling pathways linked to understanding neurodegeneration, hypertension and cancer disorders.

Applications are invited for a Postdoctoral Researchers to work in the laboratory of Dario Alessi to unravel the roles of signalling components that regulate protein phosphorylation or ubiquitylation pathways emerging from the genetic analysis of human disease.

The work would focus on analysing poorly understood signalling components mutated in human disease implicated in either neurodegeneration (LRRK2, Fbxo7, TTBK2), hypertension (WNK isoforms, SPAK/ORS1 and CUL3/KLHL3) or cancer (LKB1 and NUAK1/2/ARK5) disorders.

The aim of each project will be to understand how the above mentioned signal transduction components function and are regulated. It will also be critical to comprehend how mutations in these components cause human disease. It is anticipated that the knowledge gleaned from the successful candidates research could ultimately be exploited to devise improved strategies to treat human disease.

The successful applicants will deploy a state-of-the-art blend of biochemical, proteomic, pharmacological and genetic methodologies and technology. There would also be strong opportunities for interactions with the six major Pharmaceutical companies supporting the Division of Signal Transduction Therapy (DSTT see http://www.lifesci.dundee.ac.uk/research/dstt) to accelerate the exploitation of discoveries.

For informal enquiries please contact Dario Alessi (d.r.alessi@dundee.ac.uk). For further details on Alessi laboratory research (http://www.ppu.mrc.ac.uk/research/?pid=2) and publications (http://www.ncbi.nlm.nih.gov/pubmed?term=Alessi_dr) please peruse the indicated website links.

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU)

This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the College of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world leading researchers in the field of signal transduction have trained within the MRC-PPU. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the College of Life Sciences at the University of Dundee which is one of the premier Life Sciences research Centres in the world.

The postdoctoral positions will be for 3 years on the University of Dundee grade 7 scale (£29,541-£36,298).

Candidate requirements:

• PhD with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal
• Strong background in Biochemistry, Molecular Biology and Signal Transduction would be preferable
• Experience and strong interest in signal transduction research and how disruptions of these pathways are linked to human disease
• Capable of working in a team, but able to plan and work independently
• Excellent communication skills and knowledge of the English language are essential for this collaborative project

How to apply:

To apply on-line please visit: www.dundee.ac.uk/jobs. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number LS0271. Closing Date: 20 February 2013.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community.

The University of Dundee is a Scottish Registered Charity, No. SC015096.