美国伊利诺伊大学芝加哥分校医学院博士后职位

Job description:
Alzheimer disease research effort focused on the structure/function interactions between the human apoE isoforms and oligomeric A. Excellent opportunity for a motivated candidate to utilize a new transgenic mouse model and novel “mechanistic biomarkers” for an on-going, cross-departmental initiative focused on apoE-based therapeutic approaches to AD. In addition, validation of novel biomarkers in a large human cohort to follow disease progression is planned. An in vitro neuron/glial co-culture model will be used to both identify mechanisms underlying neuro-inflamation and neurotoxicity as well as serve as a screen for compound development, focusing in increasing apoE/A complex formation and decreasing oligomeric A.

An exceptional candidate will be innovative, dedicated and team-oriented. In addition:
1. PhD. Preferably recent graduates (salaries based on NIH scale for years post doctorate).
2. Experience in neurodegenerative diseases.
3. Working knowledge of drug screening is preferable.
4. Education/experience should be specific to cell biology, including:
a. primary CNS cell isolation and culture
b. various in vitro and in vivo imaging techniques
c. cellular trafficking
d. intracellular signaling pathways
e. analysis of protein:protein interactions.
Only candidates with these qualifications will be considered.

To apply: To be considered, applications must be received by Monday March 4th, 2013. Please send Curriculum Vitae directly to mladu@uic.edu, with a brief description of research interests, particularly as they relate to our recently published work, with background available (http://ladulab.anat.uic.edu).