美国密歇根大学白血病表观基因组学研究博士后职位

Job Summary
A post-doctoral position is available in the Figueroa lab in the Department of Pathology, University of Michigan (Ann Arbor, MI) to investigate the molecular mechanisms of epigenetic regulation of normal and malignant hematopoiesis. The laboratory focuses on studying the contribution of DNA methylation changes to the development of acute leukemias. We have recently demonstrated that leukemias have very specific DNA methylation patterns that correlate with molecular and clinical features (Cancer Cell, 2010 Jan 19;17(1):13-27, PLoS Genetics 2012 Jun;8(6)). Furthermore, we have established a mechanistic link between known mutations in AML and the establishment of aberrant hypermethylation profiles (Cancer Cell. 2010 Dec 14;18(6):553-67).
Responsibilities*
We are currently seeking a highly motivated candidate with a background in genome-wide data analysis/computational biology to study the role of epigenetic regulation in normal and malignant hematopoiesis. Projects will include next-generation sequencing based profiling studies of DNA methylation, hydroxymethylation and RNA-seq to fully characterize epigenetic changes during normal aging and in myelodysplastic syndromes. The goal of these studies is to identify epigenetically regulated programs that become deregulated during normal aging and that contribute to the development of hematopoietic malignancies. Applicants should hold a PhD and/or MD degree and have strong computational biology skills. Previous experience with epigenome-wide assays is preferred.
It is expected that the candidate will have the ability to work independently, collect and tabulate data, publish and present results, as well as to participate in the training of graduate students in a research laboratory setting.
Required Qualifications*
M.D. or Ph.D. in bioinformatics or computational biology. Evidence of scholarly ability (record of publication in peer-reviewed journals, etc.) Ability to communicate fluently in written and spoken English is absolutely required. Applications should include full curriculum vitae, publication list, information on years of experience in research and computational biology work, and names and contact information (email and telephone numbers) of 3 references.