一、单位简介

首都医学科学创新中心（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，逐步推进医教研产的深度融合，培养适应医学科学创新发展的优秀人才。

01实验室介绍

邓庆实验室现面向国内外招聘博士后与科研助理，实验室将利用深度免疫分型、单细胞及空间多组学平台、细胞分子生物学技术和遗传动物模型，解析B细胞异质性与肿瘤发展、转移以及免疫治疗效果的关联性，深入理解B细胞在肿瘤及自身免疫性疾病中的免疫调控机制，并进一步探索靶向干预B细胞成熟命运途径的潜在治疗策略。邓庆研究员本科毕业于苏州大学生命科学学院，在上海交通大学医学院获得博士学位。先后在上海人类基因组研究中心、贝勒医学院以及德克萨斯大学MD安德森癌症中心等国内外知名科研机构进行博士后研究工作，现为首都医学科学创新中心（CIMR）研究员。

02主要研究方向

肿瘤微环境中B淋巴细胞以及三级淋巴结构的特征分析，深入理解B细胞命运调控的分子生物学事件在肿瘤、自身免疫性疾病中的病理机制并提供潜在的治疗策略。

1. 调控肿瘤浸润B细胞生发中心依赖/非依赖型应答的关键分子机制与网络。

2. 三级淋巴结构中B细胞发育与筛选的机制。

3. 鉴定B细胞命运重塑的分子靶点。

03研究成果与代表性论文

1. 揭示SWI/SNF染色质重塑复合物基因突变及其调控肿瘤细胞恶性特征、命运决定的分子机制（Cancer Cell 2024, PMID: 38458188 & PMID: 38458187; Nature Genetics 2012, PMID: 22922871）。

2. 揭示CD19 CAR-T细胞与B细胞淋巴瘤治疗疗效和毒性相关联的细胞分子生物学特征（Cell Reports Medicine 2023, PMID: 37586321; Cancer Cell 2023，PMID: 37738975；Blood Advances 2023, PMID: 37389847; Nature Medicine 2020, PMID: 33020644）。

3. 鉴定不同类型B细胞淋巴瘤的免疫微环境特征，尤其是发现了与CD19 CAR-T细胞治疗后复发、肿瘤细胞突变和抗原呈递等相关联的生物学特征（Cancer Cell, Under Review; Blood Cancer Discovery 2022, PMID: 35687817）。

二、岗位信息

01博士后

1）岗位职责

1.在PI指导下独立开展课题研究；

2.协助指导实验室其他成员开展科研工作；

3.撰写论文或申请基金。

2）任职要求

1.具有生命科学或其他相关生物医学领域的研究背景，即将获得或近期已获得博士学位（原则上不超过2年）；

2.以（共同）第一作者身份在领域内主流期刊上发表过或即将发表研究论文，能够独立开展研究工作，具有科研热情和严谨的科研态度；

3.有免疫学、小鼠模型实验或多组学数据分析等研究经验者优先；

4.精通英语阅读、写作和日常沟通，能够使用英语撰写论文。

02科研助理

1）岗位职责

1.独立或协助团队开展课题研究；

2.管理和维护实验室日常工作和行政事务。

2）任职要求

1.具有生物学、基础医学、药学等相关专业的本科及以上学位；

2.掌握常规分子克隆、生物化学、细胞培养的操作及原理，有实验室研究工作经历优先；

3.有较强的主观能动性，具备良好的沟通能力和团队协作能力；

4.具备良好的英语读写和日常交流能力，能够使用英文撰写论文。

三、福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训。

四、申请方法

请将简历、个人陈述（1页）、至少2名推荐人的基本信息和联系方式、工作总结与研究兴趣（1-2页，仅限博士后），合并为PDF文件发送至qdeng@cimrbj.ac.cn，并在邮件主题中注明：“应聘博士后/科研助理+本人姓名+博士后招收网”，初审通过的申请者将会尽快安排面试。

联系人：邓庆

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

The Deng Laboratory at CIMR has open positions for postdoctoral fellows and research assistants. The laboratory primarily utilizes deep immunophenotyping, single-cell and spatial multi-omics platforms, cell & molecular biology techniques, as well as genetic animal models to investigate the role of B cell heterogeneity in tumor development, metastasis and immunotherapy response. The goal is to gain a deeper understanding of the pathological mechanism of B cells in tumorigenesis and autoimmune diseases, and to further explore potential therapeutic strategies for reprogramming B cell fate. Dr. Deng graduated from the School of Life Sciences of Soochow University and received his doctorate degree from Shanghai Jiao Tong University School of Medicine. Dr. Deng has worked as postdoctoral researcher at internationally renowned research institutions, such as Chinese National Human Genome Center at Shanghai, Baylor College of Medicine and the University of Texas MD Anderson Cancer Center. Dr. Deng has been a CIMR faculty member since March 2025.

Major Research Projects

Characterizing B lymphocytes and tertiary lymphoid structures (TLSs) in the tumor microenvironment, gaining insights into the pathological mechanisms of molecular biological events that regulates B cell fate in tumorigenesis and autoimmune diseases, and providing potential therapeutic strategies.

a. Molecular mechanisms regulating the germinal center-dependent / independent responses of tumor-infiltrating B cells.

b. Mechanisms of B cell maturation and selection in tertiary lymphoid structures.

c. Identification of molecular targets that reprogram B cell fate.

Major Academic Achievements

a. Uncovered mutated genes of SWI/SNF chromatin remodeling complex and its molecular mechanisms regulating on malignant characteristics and fate determination of tumor cells (Cancer Cell 2024, PMID: 38458188 & PMID: 38458187; Nature Genetics 2012, PMID: 22922871).

b. Identified cellular / molecular features that associated with efficacy and toxicity of CD19 CAR-T cell therapy in relapsed or refractory large B-cell lymphoma (Cell Reports Medicine 2023, PMID: 37586321; Cancer Cell 2023, PMID: 37738975; Blood Advances 2023, PMID: 37389847; Nature Medicine 2020, PMID: 33020644).

c. Characterized tumor microenvironment of different subtypes of B-cell lymphoma, specifically found biological features associated with CD19 CAR-T cell therapy, tumor cell mutation, and antigen presentation (Cancer Cell, Under Review; Blood Cancer Discovery 2022, PMID: 35687817).

Open Positions

Postdoctoral Researcher

Main Responsibilities

a. Independently conduct research projects under the guidance of the PI.

b. Mentor junior lab members to carry out experiments.

c. Write manuscripts and grant proposals.

Qualifications

a. Background in life sciences or biomedical fields. Either about to obtain a Ph.D. or recently obtained a Ph.D. degree (preferably within the past 2 years).

b. Published or submitted research papers as (co-) first author in reputable journals in the field, with motivation and ability to independently carry out research work.

c. Research experiences in immunology, mouse model, multi-omics data analysis are preferred.

d. Proficient in English reading, writing and daily communication.

Research Assistant

Main Responsibilities

a. Conducting research projects independently or in collaboration with other lab members.

b. Getting involved in lab management and maintenance.

Qualifications

a. B.S. or higher degree in biology, medicine, pharmacy and other related majors is required.

b. Research experience in molecular biology, biochemistry, cell biology is preferred.

c. Self-motivated researcher with good communication skill and teamwork ability.

d. Proficient in English reading, writing, and daily communication.

Welfare Treatment

a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).

b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Support career development, provide relevant professional guidance.

How to apply

Please combine your CV, one-page personal statement, contact information of no less than two referees and a 1-2 page research summary and interests (for postdoc applicant only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to qdeng@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name” in the email subject. Application review will begin on a rolling basis and qualified applicants will be invited for interview.

Contact person: Dr. Qing Deng

This recruitment is valid for the long term until a suitable candidate is recruited.

原文出处：

https://mp.weixin.qq.com/s/po6QtbZxC6PKMtWRciyQVw