一、中心简介

首都医学科学创新中心（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，逐步推进医教研产的深度融合，培养适应医学科学创新发展的优秀人才。

二、实验室介绍

周欣研究员先后在吉林大学、中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）获得学士和博士学位，北卡罗来纳大学教堂山分校从事博士后研究，即将加入首都医学科学创新中心（CIMR）创建独立实验室。

嵌合抗原受体细胞免疫疗法（CAR-T）是一种工程化人体免疫细胞来杀伤肿瘤的新型免疫治疗疗法，在白血病、淋巴瘤、多发性骨髓瘤中取得了备受瞩目的疗效，目前全球已有多款商业化产品，但在实体肿瘤中疗效还有诸多挑战。周欣研究员长期专注于开发和优化新型CAR-T细胞免疫疗法，探索提高CAR-T免疫疗法在实体瘤中疗效的细胞工程策略。实验室的研究以满足CAR-T在实体瘤中转化应用的迫切临床需求为导向，围绕CAR免疫疗法在实体瘤治疗中的挑战，将开展基础和转化研究。

扫码查看详情_二维码（请点击链接查看详情）

三、实验室研究方向

实验室将综合利用分子生物学、细胞生物学、流式细胞术、小鼠肿瘤模型、高通量测序等技术和手段，开展（不限）以下课题研究：

l 开发新型靶向实体肿瘤（如胰腺癌）的CAR-NKT细胞疗法；

l 探索现有两种不同CAR-T产品（以CD28和以41BB为共刺激分子）细胞通路机制，以期开发下一代CAR-T产品；

l 高通量测序筛选理解肿瘤细胞耐受CAR-T疗法的机制，以期指导靶向联合治疗手段。

四、主要成果与贡献

1.成功构建小鼠CAR-NKT细胞平台，并证明其可以通过调控肿瘤微环境，在多种实体肿瘤中展现出更强的抗肿瘤效果（Nature Cancer, 2024）。

2.通过修改优化CAR分子结构来增强CAR-T治疗的疗效（Journal for Immunotherapy of Cancer, 2021; Nature Cancer, 2021; Cellular & Molecular Immunology, 2024）（专利，2021, WO2023199069A1）。

3.探索调控巨噬细胞中炎症产生的新的分子机制以及在炎症相关疾病中的作用的功能（Cell Reports, 2019, 2020; The Journal of Clinical Investigation, 2015）。

五、代表性文章

Nature Cancer, 2024 Nov; 5(11): 1607-1621.PMID: 39354225.

Cellular & Molecular Immunology, 2024 Aug; 21(8): 905-917.PMID: 38937625.

Journal for Immunotherapy of Cancer, 2021 Apr; 9(4): e002173.PMID: 33795386.

Cell Reports.2019 Apr 23; 27(4): 1176-1189.e5.PMID: 31018132.

六、岗位信息

01助理研究员

1）主要职责

1.在PI指导下独立开展研究工作；

2.协助指导研究生工作以及撰写论文或基金申请；

3.协助PI管理实验室。

2）任职要求

1.以第一作者身份在领域内主流期刊上发表过研究论文；

2.有小鼠肿瘤模型，免疫治疗，AAV基因治疗等实验背景者优先考虑；

3.具备独立开展科研工作和指导研究生能力，有实验室管理经验优先考虑；

4.具备流利的英语读写和日常交流能力，能够使用英文撰写论文。

02博士后

1）主要职责

1.在PI指导下独立开展研究工作；

2.协助指导研究生工作以及撰写论文或基金申请。

2）任职要求

1.具有生命科学或其他相关生物医学领域的研究背景，即将获得博士学位或已获得博士学位（原则上不超过3年）；

2.以第一作者身份在领域内主流期刊上发表过或即将发表研究论文，能够独立开展研究工作；

3.具备独立开展科研工作和指导研究生能力，具有科研热情和严谨的科研态度；

4.熟练掌握分子生物学、免疫细胞培养、动物实验基本操作和原理；

5.具备良好的英语读写和日常交流能力，能够使用英文撰写论文。

七、福利待遇

1.根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2.享受五险一金、带薪年假、体检和补充医疗保险等；

3.支持个人职业发展，提供必要的工作相关专业培训。

八、申请方法

应聘者请将个人简历、研究兴趣或计划，以及2-3名推荐人（仅限博士后应聘）的姓名及联系方式，以及其他能证明科研能力的相关电子文件发送到邮箱zhouxin@cimrbj.ac.cn，邮件主题请注明“应聘者名字+具体应聘职位+博士后招收网”。

联系人：周老师

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

另外本实验室欢迎有对细胞免疫疗法感兴趣的各阶段实习生、联培生前来学习交流。

ABOUT CIMR

The Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment.For more information, please visit our website: www.cimrbj.ac.cn

Laboratory Introduction

Chimeric antigen receptor cell immunotherapy (CAR-T) is a new type of immunotherapy that engineers’ human immune cells to kill tumors.It has achieved remarkable results in leukemia, lymphoma, and multiple myeloma, and there are currently many commercial products worldwide.However, significant challenges remain in enhancing its efficacy against solid tumors.The Zhou Laboratory at CIMR is dedicated to developing and optimizing next-generation CAR-T cell therapies, with a particular focus on innovative cell engineering strategies to improve their effectiveness in solid tumors.

Lab website：

QR code（请点击链接查看详情）

Major Research Projects

The laboratory will comprehensively utilize molecular biology, cell biology, flow cytometry, mouse tumor models, high-throughput sequencing, and other technologies and methods to research the following topics (not limited):

a.Explore the potential of CAR-NKT cell therapy in pancreatic cancer and other solid tumors.

b.Develop and refine new strategies to enhance CAR-T cell persistence, improving the effectiveness of CAR-T therapy in solid tumors.

c.High-throughput sequencing screening to understand the mechanism of tumor cell tolerance to CAR-T therapy, to guide targeted combined treatment methods.

Major Contributions

a.Generating the murine CAR NKT platform and demonstrating their superior anti-tumor effect in multiple solid tumors via programming the tumor microenvironment (Nature Cancer, 2024).

b.Enhancing the efficacy of CAR-T treatment by modifying CAR structure (Journal for Immunotherapy of Cancer, 2021; Nature Cancer, 2021; Cellular & Molecular Immunology, 2024) (Patent, 2021, WO2023199069A1).

c.Identifying the new mechanism to regulate inflammation and macrophage polarization (Cell Reports, 2019, 2020; The Journal of Clinical Investigation, 2015).

Representative Publications

Nature Cancer, 2024 Nov; 5(11): 1607-1621.PMID: 39354225.

Cellular & Molecular Immunology, 2024 Aug; 21(8): 905-917.PMID: 38937625.

Journal for Immunotherapy of Cancer, 2021 Apr; 9(4): e002173.PMID: 33795386.

Cell Reports.2019 Apr 23; 27(4): 1176-1189.e5.PMID: 31018132.

Open Positions

Research Assistant Investigator

Main Responsibilities

a.Ability to independently conduct scientific research and guide graduate students, experience in laboratory management is preferred

b.Getting involved in lab data analysis and management.

c.Assist in guiding other lab members and writing papers or funding applications.

Qualifications

a.Published or about to publish research papers as the first author in reputable journals in the field.

b.Research experience in mouse tumor models, immunotherapy, AAV gene therapy etc.are preferred.

c.Self-motivated researcher with good communication skills and teamwork ability.

d.Proficient in English reading, writing, and daily communication.

Postdoctoral Researcher

Main Responsibilities

a.Conducting research projects independently.

b.Assisting PI to mentor graduate students, and write grant proposals and manuscripts.

Qualifications

a.Backgrounds in biology or biomedical fields.Either about obtaining a Ph.D.or recently obtaining a Ph.D.degree (ideally within the last 3 years).

b.Published or about to publish research papers as the first author in reputable journals in the field.

c.Have the ability to independently carry out scientific research and guide graduate students and have scientific research enthusiasm and rigorous scientific research attitude.

d.Strong research experience in molecular biology, immune cell culture, FACS, and mice experiments.

e.Proficient in English reading, writing, and daily communication.Capable of writing papers in English.

Welfare Treatment

a.Competitive salary based on the applicant’s work experience and ability (salary negotiable).

b.Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c.Opportunities for career development and available professional guidance.

How to apply

To apply, please send a personal resume, research interest or plan, the names and contacts of 2-3 referees, and other materials demonstrating research capabilities to zhouxin@cimrbj.ac.cn and indicate the applicant's name and specific job position in the email subject.

Contact Person: Xin Zhou

This recruitment is valid for the long term until a suitable candidate is recruited.

Additionally, our laboratory welcomes interns and joint trainees at all stages who are interested in cellular immunotherapy to come and exchange ideas.

原文出处：

https://mp.weixin.qq.com/s/WqffOH7gNRlMAS8uMYLdnQ